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On top of that, the indole Main is substituted at R3 that has a carbonyl group which can be also bonded to some napthalene moeity. Napthalene is really a bicyclic framework of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it being a ketone. JWH-018 is undoubtedly an analog of THJ-018, through which the Main indazole framework